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Introduction to Literature Search

This guide is intended to provide you with the basic skills necessary to search for literature. The skills are presented broadly and can be applied across all databases.

Strategies for Searching

Stuck looking for information? Here you will find strategies and techniques to help with database searching. Experiment with these strategies and techniques across multiple databases. What doesn't work in one place might work in another.

Searching Strategies Overview

There are a number of different sources that can be searched for literature, including:

  • Citation Databases - you should search across a range of databases, as no one database covers all the related literature. Your choices regarding which databases to search will depend on the topic of your paper. It is important that your searches in these databases is both comprehensive and reproducible. See Netter Library's Complete List.
  • Clinical Trials - many clinical trials remain unpublished. It is important to include unpublished and ongoing studies to minimize potential bias
    • Cochrane Library
    • Clinicaltrails.gov
  • Grey Literature  - information not controlled by commercial publishing that is produced by organizations, governments, and industry. Examples of grey literature include
    • ​conference papers
    • reports
    • theses
    • government publications
    • fact sheets
    • statistics
    • research in progress
    • Learn more about Grey Literature 

Adapted from RMIT University's Systematic Reviews in Health Research Guide.

Keywords 

  • natural language terms used to describe your topic
  • can be combined a number of ways
  • used when no appropriate subject heading exists
  • sometimes too broad or too narrow

When searching, keywords can be used to...

  • Search for singular and plural terms together
  • Search for terms with different spellings
  • Search for synonyms of terms together
  • Search for phrases inside of quotation marks

Subject Headings

  • also known as "controlled vocabulary"
  • used by an organization to describe the concepts in the literature collected by that organization
  • consistent in their definition across the records in the organization's database
  • less flexible than keywords -- need to know the exact term to use (some databases have 'entry terms' that will connect the subject heading to term you've entered)
  • a method to yield results very relevant to your topic

Databases that use subject headings

Boolean Operators

  • Use to COMBINE TOGETHER separate topics. 
  • Narrows your search
  • Finds results that include ALL of your terms

Examples:

  • Cat AND Dog
  • Exercise AND Heart Attacks
  • Use tto CONNECT SYNONYMS or related ideas
  • Broadens your search
  • Finds results that include ANY of your terms

Examples: 

  • (Cat OR Dog)
  • (Exercise OR Workout OR Aerobics)
  • Use to REMOVE TERMS from the search results
  • Narrows your search
  • Further defines your term -- good for terms that might have multiple meanings

Examples:

  • Cat NOT Dog
  • Nursing NOT breastfeeding 

 

Phrase Searching

  • Also known as quotation searching 
  • Uses quotes " " to search for an exact phrase
  • Useful when paired with OR
  • The quotations "lock" in your terms and tell the database to retrieve results that have your terms appear exactly as they do in the quotations

A search for attention deficit disorder = attention AND deficit AND disorder  -- without phrase searching

A search for "attention deficit disorder" = "attention deficit disorder" -- with phrase searching

Truncation

  • Uses a symbol to search for all possible forms of a word
    • Frequently used symbols include asterisk (*), a question mark (?), or a dollar sign ($)
  • Broadens your search
  • Useful to find alternate endings or plural form of a word
  • Different databases use different symbols. Check the database's 'Help' or 'Search tips' pages for details on which symbol to use

Example: Child* = child, child's, childhood, children, children's, 

Note: The placement of the truncation symbol can impact the type of results you get back.

Example: If I searched Hum* with the expectation of getting versions of 'Human', I'd also get.... 

  • Humans
  • Humanoid
  • Humorous
  • Humor
  • Hummus

Wildcards

  • Use symbols to represent a letter or letters in a word
  • Broadens your search
  • Useful when searching with words that have different spellings
  • Frequently used wildcard symbols include question marks (?), the pound symbol (#), or the astrisk (*)
  • Different databases use different symbols. Check the database's 'Help' or 'Search tips' pages for details on which symbol to use

Examples:

  • wom#n = woman or women
  • col?r = color or colour

MeSH Terms

What is MeSH?

Also known as Medical Subject Headings, MeSH is the U.S National Library of Medicine's (NLM) controlled vocabulary used to index journals in MEDLINE/PubMed. These terms provide a consistent way to find articles that have utilize different terminology for the same concepts. MeSH is assigned to each articles by by subject analysts when applicable. It typically can take anywhere from 3 to 6 months for MeSH terms to be applied to an article, creating a delay.

Check out this tutorial from the National Library of Medicine to learn more about MeSH: https://www.nlm.nih.gov/bsd/disted/meshtutorial/introduction/index.html

How to use Medical Subject Headings (MeSH) in PubMed

The MeSH Database is accessible directly from PubMed's homepage. In the MeSH database, you can:

  • Locate and select MeSH terms 
  • View definitions, scope, and relationships of a given MeSH term
  • Select subheadings to build a more specific search

In the next tab, I will outline how to search for MeSH terms in PubMed. For an alternative experience, please check out this video from NCBI that walks you through using the MeSH databaseNote: this video was made prior to the update of PubMed. Although PubMed looks different now, the MeSH database has not changed. 

Medical Subject Headings (MeSH) in PubMed

Step 1: Locate and Search for Terms in the MeSH Database

The easiest way to access the MeSH database is by using the link on PubMed's homepage, located right under the Explore icon.

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Search for one term at a time. Although the MeSH database is extensive, it is important to note that not every term is going to have a corresponding MeSH term.

Results will be displayed with brief definitions, ranked by relevance. Select the entry that best fits your needs to view the full record page. If there is only one result available, you will be brought directly into the record

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Step 2: Review the MeSH Record

At the top of the MeSH recored page, you will see the term's definition and a list of subheadings. Scroll down to view Entry Terms (if available) and the MeSH Hierarchy.

  • Entry Terms: terms that, when used to search in the MeSH database, will "map" to the current MeSH term
  • MeSH Hierarchy: displays a hierarchy tree and where your term falls within it. The MeSH Hierarchy is very helpful for those who may not be familiar with their topic. The hierarchy shows the term in a variety of contexts

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Step 3: Refine your Search with the MeSH Record

There are three possible options for refining your search with the MeSH record:

  • Apply one or more subheadings: Adding subheadings to a MeSH term allows you to focus your search to those specific topics. If you do not apply any subheadings, PubMed will include all of them when it searches for your MeSH term
  • Restrict to MeSH Major Topic: This will retrieve only citations where your subject is one of the main topics featured in an article
  • Choosing the option "Do not include MeSH terms found below this term in the MeSH hierarchy: Only do this if you do not want PubMed to search for the narrower terms that appear beneath your MeSH term in the MeSH hierarchy
Step 4: Search for your MeSH Terms in PubMed

When you are ready, click the "Add to Search Builder" button located right under the PubMed Search Builder box, found on the right side of the screen. If you are using any subheadings, be sure to check their boxes  prior to select "Add to Search Builder". 
If you are ready to search for your MeSH term in PubMed, select the Search PubMed.

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Keywords vs Subject Headings Example

Keyword Medical Subject Heading (MESH) CINAHL Subject Heading
Heart attack Myocardial infarction Myocardial infarction
Distance education Education, non-traditional Education, distance
EHR Computerized Patient Record  Electronic Health Records

Evaluate your search strategy

Check your search strategy for efficiency by using the checklist below!

PRESS Peer Review of Electronic Search Strategies (2016)

McGowan J, Sampson M, Salzwedel DM, Cogo E, Foerster V, Lefebvre C. PRESS Peer Review of Electronic Search Strategies: 2015 guideline statementJournal of Clinical  Epidemiology, 75, 40-46