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Biomedical Sciences

Basic library information and resources for Biomedical Sciences.

Research Steps Overview

This diagram illustrates general steps of a research process.

Develop and Refine a Research Question

To build a research question, you can start from a big topic of your interest.

Once you have the topic, you need some basic background knowledge to know the field that you are going to focus.

Where to find background knowledge:  

  • Review articles: use the library OneSearch to find journal review articles. If Google, check who published the information and evaluate the sources (Don't know how to evaluate online information? Please visit Evaluation Resources from the Internet. )
  • Book chapters

After you have some background information, you will work on your research question and finally ask a manageable one.

Check the video below on choosing a manageable question. 

Find Information (Literature Search)

After you have a preliminary question, you will need to do a literature search. 

1. What databases to search (general rule):

For interdisciplinary questions: OneSearch, Scopus, Google Scholar

  • OneSearch is the library discovery tool which searches across our physical collections and most of electronic resources. It is EBSCO Discovery Service. 

New EBSCO Discovery Service (EDS)- Quick Start Guide

Concept Map - Quick Start Guide  "The primary purpose of Concept Map is to allow users to interactively and visually explore related concepts to construct effective EDS search queries..."

  • Scopus provides access to peer-reviewed research and conference literature in the sciences, social sciences, and humanities.

For biomedical questions: PubMed, CINAHL (For Nursing and Allied Health profession)

Please visit ABL A-Z Databases for all subjects. 

2. General literature search strategy:

Step 1.Identify key concepts and list them in a table (see an example below).
Step 2.Collect search terms for each concept (use Boolean OR) and add them in the table.
Step 3.Search each concept (PubMed) or enter each concept in one line (OneSearch, Ebscohost platform, or other databases).
Step 4.Combine concepts (use Boolean AND).

Step 5. Apply filters.

Note: remember to save your search strategy in a file.  

Example research question: How does omega-3 fatty acid intake affect cognitive performance in adolescents?

Key concepts

Search terms

omega-3 fatty acids

(omega-3 fatty acids) OR (alpha-linolenic acid) OR ALA OR (eicosapentaenoic acid) OR EPA OR (docosahexaenoic acid) OR DHA OR (polyunsaturated fatty acids) OR PUFAs OR (fish oil)

cognitive performance

(cognitive performance) OR (academic performance) OR (school performance) OR cognition OR Learning

adolescents

Use the age filter.

Create Hypotheses/Theories

After you gained thorough background information, the next step is to formulate a clear, testable statement that predicts a relationship between variables. It can be structured as an "if-then" statement, defining the independent and dependent variables involved. It is a possible answer or explanation for your research question which then becomes your hypothesis. In other words, it can be your prediction of your experiment results. In some studies, theories can be developed. A theory is a more comprehensive explanation supported by evidence, while a hypothesis is a specific, testable prediction based on that theory. To know more about theory, check Chapter 3 The use of Theory in Research design: Qualitative, quantitative, and mixed methods approaches. 

Creswell, J. W., & Creswell, J. D. (2018). Research design : qualitative, quantitative, and mixed methods approaches / John W. Creswell, Department of Family Medicine, University of Michigan, J. David Creswell, Department of Psychology, Carnegie Mellon University. SAGE Publications, Inc.

How to craft a research hypothesis

Here are some strategies provided by Elsevier Author Services:

  • A hypothesis can use the if/then format when it seeks to explore the correlation between two variables in a study primarily. 

Example: If administered drug X, then patients will experience reduced fatigue from cancer treatment. 

  • A hypothesis can adopt when X/then Y format when it primarily aims to expose a connection between two variables 

Example: When workers spend a significant portion of their waking hours in sedentary work, then they experience a greater frequency of digestive problems. 

  • A hypothesis can also take the form of a direct statement. 

Example: Drug X and drug Y reduce the risk of cognitive decline through the same chemical pathways 

To know more about this topic, like types of hypotheses: null hypothesis and alternative hypothesis, please visit Step-by-Step Guide: How to Craft a Strong Research Hypothesis.

Design Research

To prove a hypothesis, you will need to design your research, collect and analyze data. There are two types of hypotheses: null hypothesis and the alternative hypothesis. 

Research design is the strategy to collect, study, and evaluate data of your research. Based on the type of data collected and analyzed, research design can be broadly classified into qualitative research, quantitative research and mixed methods research.

Qualitative research involves collecting and analyzing non-numerical data (e.g., text, video, or audio) to understand concepts, opinions, or experiences. It can be used to gather in-depth insights into a problem or generate new ideas for research. It is commonly used in the humanities and social sciences, in subjects such as anthropology, sociology, education, health sciences, history, etc. Qualitative research methods include interviews, documents, focus groups, case study research, and ethnography.

Quantitative research collects and analyzes numerical data. It can be used to find patterns and averages, make predictions, test causal relationships, and generalize results to wider populations. It is widely used in the natural and social sciences: biology, chemistry, psychology, economics, sociology, marketing, etc. Quantitative research methods include surveys and experiments. Experiments typically yield quantitative data. Other research methods, such as controlled observations and questionnaires, can produce both quantitative and qualitative information.

Mixed methods research involves combining or integrating qualitative and quantitative research and data in a research study.

Note: the table is from Table 1.3 Quantitative, Mixed and Qualitative Methods in Chapter 1 (Page 11) in Research design: Qualitative, quantitative, and mixed methods approaches. (Chapter 1 is available as preview in Google Books. The print book is in QU library collection.)

The above research methods in this research guide only gives you a brief overview of research design. To know more about it, please check the following resources:

Creswell, J. W., & Creswell, J. D. (2018). Research design : qualitative, quantitative, and mixed methods approaches / John W. Creswell, Department of Family Medicine, University of Michigan, J. David Creswell, Department of Psychology, Carnegie Mellon University. SAGE Publications, Inc.

Qualitative vs Quantitative Research: What’s the Difference? (2023, December 18). https://www.simplypsychology.org/qualitative-quantitative.html

Carson, H. (n.d.). Subject and Course Guides: Quantitative and Qualitative Research: What is Quantitative Research? Retrieved January 6, 2025, from https://libguides.uta.edu/quantitative_and_qualitative_research/quant

Collect & Analyze Data

Every research collected data, either from the literature or the subject being studied. Data can be broadly categorized into two types: primary data and secondary data.

Primary data is collected firsthand through methods such as: experiments, questionnaires, observations and interviews in primary studies.

Secondary data is derived from existing sources, such as literature and reports.

Data analysis in the biomedical field follows a similar process to other fields. First, it’s essential to grasp the fundamentals of statistics to understand data distributions, hypothesis testing, and key analysis methods. Next, learn programming languages like Python or R, or software tools for data analysis. Then you will focus on biomedical-specific tools and datasets, such as those related to genomics, clinical data, and epidemiology. Finally, you should practice using real-world biomedical data through projects or case studies, to enhance problem-solving abilities and understanding of the field.

Coursera courses:

Python Basics

Programming for Everybody (Getting Started with Python)

Note: Coursera offers student plan which includes one free course per year. You may also apply financial aid for some courses. 

Write a Manuscript

A research paper or manuscript represents the culmination of your study. Planning for your manuscript should begin on the first day of your research. Here are some tips to help streamline the writing process:

  • Use Citation Management Software

Start using a citation management tool, such as Zotero, to organize references from the beginning. Zotero helps keep all your citations in one place, and it can insert in-text citations and generate a reference list. For guidance on using Zotero, visit the Library Zotero Guide.

  • Develop and Refine Your Outline

While reviewing the literature, identify key points or concepts you may want to include in your research. Write down your ideas and use them to draft an initial outline for your research paper. Continuously revise and refine this outline as your research progresses to ensure it aligns with your findings and objectives. 

  • Conduct Ongoing Literature Searches

Be prepared to perform additional literature searches as your research unfolds. New topics or gaps may emerge, requiring you to find relevant studies and incorporate them into your work.

Starting early with a clear plan can make writing your biomedical research paper more efficient and less stressful.